Manifold for Good

Positively influence the long-term trajectory of civilization by making grants that address global catastrophic risks.

The Quantified Uncertainty Research Institute advances forecasting and epistemics to improve the long-term future of humanity.

Accelerating the development of each vaccine by even a couple of days via COVID-19 human challenge trials could save thousands of lives.

Incubate longtermist nonprofits by connecting founders with ideas, funding, and mentorship.

Send money directly to people living in poverty.

We help protect people from malaria.

We search for the charities that save or improve lives the most per dollar.

We help everyone share in the sum of all knowledge.

We envision a world where no one is deprived of the opportunity to live a healthy life – and reach their true potential.

We specialise in the prevention, control and treatment of malaria and other communicable diseases.

We provide independent, impartial medical humanitarian assistance to the people who need it most.

Direct Relief is a humanitarian aid organization, active in all 50 states and more than 80 countries, with a mission to improve the health and lives of people affected by poverty or emergencies – without regard to politics, religion, or ability to pay.

WWF works to sustain the natural world for the benefit of people and wildlife, collaborating with partners from local to global levels in nearly 100 countries.

Feeding everyone no matter what.

Align future machine learning systems with human interests.

A Future Where People and Nature Thrive

For over 70 years, we've led the world by making life-changing breakthroughs in cancer research and patient care, providing the most advanced treatments available.

Support and fund research on how ideology and government policy contribute to scientific, technological, and social progress.

The Free Software Foundation (FSF) is a nonprofit with a worldwide mission to promote computer user freedom.

Providing vital support to high-impact charities and charitable projects.

Faunalytics conducts research and shares knowledge to help advocates help animals effectively.

We exist to end the abuse of animals raised for food by influencing the policies of the world’s biggest companies, demanding legislation, and empowering others to take action and leave animals off their plates

We want to make life better for wild animals.

Cash incentives to boost vaccination rates and save lives.

SCI works with governments in sub-Saharan Africa to create or scale up programs that treat schistosomiasis and soil-transmitted helminthiasis ("deworming").

Rainforest Trust saves endangered wildlife and protects our planet by creating rainforest reserves through partnerships, community engagement and donor support.

UNICEF USA helps save and protect the world's most vulnerable children.

By improving access to vital nutrition, everyone gets an equal chance to grow, thrive, and prosper.

WRI is a global nonprofit organization that works with leaders in government, business and civil society to research, design, and carry out practical solutions that simultaneously improve people’s lives and ensure nature can thrive.

The mission: to expose abuses of power and betrayals of the public trust by government, business, and other institutions, using the moral force of investigative journalism to spur reform through the sustained spotlighting of wrongdoing.

Through the decades, Save the Children has continued to work to save children’s lives, and that’s still what we do today.

WCK is first to the frontlines, providing meals in response to humanitarian, climate, and community crises. We build resilient food systems with locally led solutions.

Our mission: to protect people’s health from epidemics and disasters and ensure that communities are resilient to major challenges.